科研之友
微信
新浪微博
Facebook
分享链接
摘要
Background: Hip dysplasia is a disease characterized by laxity of the joint and subsequent development of osteoarthritis. Pain is initially caused by joint looseness and instability. Dorsal acetabular denervation surgery have been used with an analgesic objective. The technique initially proposed was modified, by performing a larger area of denervation. There are no studies referring to the pain parameters accepted by researchers regarding the assessment of this technique are available in the literature. The aim of this research was express by cortisol and serum glycemia levels, the remission of pain in the patients submitted to acetabular denervation.
Materials, Methods & Results: The serum levels of cortisol and glycemia were analyzed in 11 dogs with hip dysplasia at moments 0 (M0), I (M1), II (M2) and III (M3), which were respectively the moment of the diagnosis, 2, 7 and 15 days after the surgical procedure. All the patients were sumitted to the surgical intervention called dorsal acetabular denervation. The colorimetric enzymatic method was used for glucose measurement and the reading was performed using a spectrum photometer. For the serum measurement of cortisol the ELISA method was used. The statistical analyses were processed with the help of a computerized statistical program (Minitab Release 13). The final data obtained were analyzed regarding their parametric distribution using the Kolmogorov-Smirnov test. The analyzed data presented a parametric distribution and had means compared by the Tukey's analysis of variance. Differences with P values equal or smaller than 0.05 were considered significant. The correlation between the glycemia and serum cortisol values was evaluated by the Pearson test. The statistical analysis of the results points out a significant difference regarding the cortisol levels (mu g/dL) at moments M1 and M2 regarding the moment M0, and at moment M3 regarding the other moments. There was no significant statistical difference for the analyzed moments regarding the glycemia (mg/dL) of the patients. There was a low correlation between the serum glycemia and cortisol levels when compared by the Pearson correlation test.
Discussion: The denervation of the coxofemoral joint capsule has demonstrated satisfying clinical effects. However, the evaluations presented are subjective, demonstrating only the indications of questionnaires and physical examinations, not evaluating the cessation of the algesic state presented by these patients in a qualitative and quantitative manner, like we did in this research. The pain can be considered a stress factor and hence results in a neuroendocrine response due to the stimulus of the hypothalamus-hypophysis-adrenals axis leading to an increase in the plasmatic levels of cortisol. The reason why the measurement of cortisol is an excellent parameter for the assessment of the neuroendocrine modulation of pain. In the present study, it was possible to demonstrate the lowering of the serum levels of cortisol at moment M1 regarding the M0, and the same fact was repeated at moment M2. The repetition of the difference at the M3, with no use of any analgesic agents, shows the efficacy of the procedure. The results pointed out corroborate the ones described by others researchers, in which in 7 days after the surgical intervention, owners reported that the animal presented good or very good quality of life in 51% of the evaluated cases. Animals presenting better quality of life, with no apparent pain demonstrate which is also satisfying to their owners who, in all cases, reported a decrease in their personal suffering that they experienced while watching their animals suffer. The modified dorsal acetabular denervation technique was effective in reducing pain in eleven dogs with hip dysplasia.
- 出版日期2015-4-13
