科研之友
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摘要
Background: Genetic and environmental factors, including dietary copper intake, contribute to the pathogenesis of copper- associated hepatitis in Labrador retrievers. Clinical disease is preceded by a subclinical phase in which copper accumulates in the liver. Objective: To investigate the effect of a low-copper, high-zinc diet on hepatic copper concentration in Labrador retrievers with increased hepatic copper concentrations. Animals: Twenty-eight clinically healthy, client-owned Labrador retrievers with a mean hepatic copper concentration of 919 +/- 477 mg/kg dry weight liver (dwl) that were related to dogs previously diagnosed with clinical copper-associated hepatitis. Methods: Clinical trial in which dogs were fed a diet containing 1.3 +/- 0.3 mg copper/Mcal and 64.3 +/- 5.9 mg zinc/Mcal. Hepatic copper concentrations were determined in liver biopsy samples approximately every 6 months. Logistic regression was performed to investigate effects of sex, age, initial hepatic copper concentration and pedigree on the ability to normalize hepatic copper concentrations. Results: In responders (15/28 dogs), hepatic copper concentrations decreased from a mean of 710 +/- 216 mg/kg dwl copper to 343 +/- 70 mg/kg dwl hepatic copper after a median of 7.1 months (range, 5.5-21.4 months). Dogs from a severely affected pedigree were at increased risk for inability to have their hepatic copper concentrations normalized with dietary treatment. Conclusions and Clinical Importance: Feeding a low-copper, high-zinc diet resulted in a decrease in hepatic copper concentrations in a subset of clinically normal Labrador retrievers with previous hepatic copper accumulation. A positive response to diet may be influenced by genetic background. Determination of clinical benefit requires further study.
- 出版日期2015-6
