A Facile Synthesis of 3-Substituted 9H-Pyrido[3,4-b]indol-1(2H)-one Derivatives from 3-Substituted beta-Carbolines

作者：Lin, Guowu; Wang, Yue; Zhou, Qingfa; Tang, Weifang; Wang, Jian; Lu, Tao^*

来源：Molecules, 2010, 15(8): 5680-5691.

DOI：10.3390/molecules15085680

• beta-carboline
• beta-carbolinone
• rearrangement
• electron-withdrawing
• X-ray crystal structure

A mild and efficient two-step synthesis of 3-substituted beta-carbolinone derivatives from 3-substituted beta-carboline in good yields is described. A possible reaction mechanism for the formation of the skeleton of beta-carbolin-1-one is proposed. The structures of these compounds were established by IR, H-1-NMR, C-13-NMR, mass spectrometry and elemental analysis, as well as X-ray crystallographic analysis of 4-2 and 6-2.

• 出版日期2010-8
• 单位中国药科大学