Aggregation induced photodynamic therapy enhancement based on linear and nonlinear excited FRET of fluorescent organic nanoparticles

作者：Hsieh Meng Chieh^*; Chien Cheng Hao; Chang Cheng Chung; Chang Ta Chau

来源：Journal of Materials Chemistry B, 2013, 1(18): 2350-2357.

DOI：10.1039/c3tb00345k

A binary molecule can self-assemble to form fluorescent organic nanoparticles (FONs) based on the Aggregation-Induced Emission Enhancement (AIEE) property and subsequently, presents an efficient fluorescence resonance energy transfer (FRET) to generate singlet oxygen under linear and nonlinear light sources. Biologically, this FON-photosensitizer is much more phototoxic to cancer cells than to normal cells without significant dark toxicity. Eventually, a new approach, called FON FRET-PDT or AIEE FRET-PDT, to promote the PDT effect is expected.

• 出版日期2013
• 单位中国科学院