Memory Decline in Down Syndrome and Its Relationship to iPF2alpha, a Urinary Marker of Oxidative Stress

作者：Zis Panagiotis^*; McHugh Patrick; McQuillin Andrew; Pratico Domenico; Dickinson Mark; Shende Sima; Walker Zuzana; Strydom Andre

来源：PLos One, 2014, 9(6): e97709.

DOI：10.1371/journal.pone.0097709

Background: Lipid peroxidation may be a marker of free-radical-mediated injury associated with Alzheimer%26apos;s disease (AD). We aimed to investigate whether changes in lipid peroxidation is associated with cognitive decline in individuals with Down syndrome over a 4-year period. %26lt;br%26gt;Methods: Thirty-two adults with DS participated in a longitudinal study with urinary isoprostane 8,12-iso-iPF2alpha (iPF2alpha) assays at baseline and four years follow-up. Informants rated their functional ability and memory function and the adults with DS attempted assessments of language skills and memory. Twenty-six individuals completed assessments of memory (Modified Memory Object Task, MOMT), adaptive behavior (ABAS), and receptive vocabulary (British Picture vocabulary, BPVS) at both time-points. %26lt;br%26gt;Results: Overall change in iPF2alpha level was negatively correlated with change in the MOMT score (Spearman%26apos;s Rho = -0.576, p = 0.006), i.e., increased lipid peroxidation was correlated with worse memory functioning over time. An increase of %26gt;= 0.02 ng/mg creatinine iPF2 alpha had good sensitivity (85.7%), positive predictive value (75%,), specificity (85.7%) and negative predictive value (92.3%) for memory decline. %26lt;br%26gt;Conclusion: Change in iPF2alpha over time may have potential as a biomarker for memory decline in Down syndrome and potentially also help to track progression of MCI to AD in the general population.

• 出版日期2014-6-5