Antioxidant and Pro-Oxidant Evaluation of a Potentilla alba L. Rhizome Extract

作者：Dorman H J Damien^*; Shikov Alexander N; Pozharitskaya Olga N; Hiltunen Raimo

来源：Chemistry and Biodiversity, 2011, 8(7): 1344-1356.

DOI：10.1002/cbdv.201100043

Using spectrophotometric methods, a H(2)O-soluble Potentilla alba L. rhizome extract was evaluated phytochemically, i.e., the total phenol, flavonoid, flavonol, flavanone, and proanthocyanidin contents were determined, and its antioxidant and pro-oxidant properties, i.e., the Fe(III) reductive and the Fe(II) chelating properties, the 1,1-diphenyl-2-picrylhydrazyl radical (DPPH(center dot)), N,N-dimethyl-p-phenylenediamine (DMPD(center dot+)), and superoxide anion radical (O(2)(center dot-))-scavenging activities, the capacity to inhibit hydroxyl radical (HO(center dot))-mediated deoxy-D-ribose and phospholipid degradation, and the interaction with the Cu-catalyzed HO(center dot)-mediated DNA degradation, were determined. The extract was found to contain a range of phenolic compounds recognized to possess strong antioxidant-like properties. Moreover, the extract demonstrated dose-dependent activities in all the antioxidant assays with the exception of the DNA-degradation assay, where the components within the extract interfered with the assay components at concentrations >= 1.00 mg/ml. Potentilla species are known for their curative properties, with aerial/subterranean parts being prescribed for numerous indications. The data presented here suggests, though does not conclude, that the rhizomes contain compounds possessing a range of antioxidant-related properties, which may underpin the therapeutic, viz., anti-inflammatory and adaptogenic effects, ascribed to species of this genus.

• 出版日期2011-7