A novel passerivirus (family Picornaviridae) in an outbreak of enteritis with high mortality in estrildid finches (Uraeginthus sp.)

作者：Pankovics Peter; Boros Akos; Tung Gia Phan; Delwart Eric; Reuter Gabor^*

来源：Archives of Virology, 2018, 163(4): 1063-1071.

DOI：10.1007/s00705-017-3699-0

• Passerivirus
• Dead bird
• Estrildid finch
• Picornavirus
• Gastroenteritis

An enteric outbreak with high mortality (34/52, 65.4%) was recorded in 2014 in home-reared estrildid finches (Estrildidae) in Hungary. A novel passerivirus was identified in a diseased violet-eared waxbill using viral metagenomics and confirmed by RT-(q)PCR. The complete genome of finch picornavirus strain waxbill/DB01/HUN/2014 (MF977321) showed the highest amino acid sequence identity of 38.9%, 61.6%, 69.6% in P1(cap), 2C(hel) and 3C(pro)D(pol), respectively, to passerivirus A1 (GU182406). A high viral load (6.58 x 10(10) genomic copies/ml) was measured in a cloacal specimen and in the tissues (spinal cord, lung, and the intestines) of two additional affected finches. In addition to intestinal symptoms (diarrhoea), the presence of extra-intestinal virus suggests a generalized infection in this fatal disease, for which the passerivirus might be a causative agent.

• 出版日期2018-4