Application of P-chirogenic bisphospholane ligands to rhodium catalyzed asymmetric hydrogenation of alpha- and beta-acetamido dehydroamino acid derivatives

作者：Hoge G^*; Samas B

来源：Tetrahedron: Asymmetry , 2004, 15(14): 2155-2157.

DOI：10.1016/j.tetasy.2004.04.041

Two previously reported P-chirogenic bisphospholane rhodium catalysts have been applied to the asymmetric hydrogenation of alpha- and beta-acetamido dehydroamino acid derivatives. For alpha-acetamido dehydroamino acid derivatives, catalyst 4 produced very high enantiomeric excesses. These are contrasted with the previously reported enantiomeric excesses using catalyst 2. Both catalysts provide excellent enantioselectivity (96%) for the beta-acetamido dehydroamino acid derivative, (E)-methyl 3-acetamido-2-butenoate. However, catalyst 2 produces higher enantio selectivity (89%) for the (Z)-isomer when compared to catalyst 4 (83%).

• 出版日期2004-7-26