Association between genetic polymorphisms in androgen receptor gene and the risk of preeclampsia in Korean women

作者：Lim Ji Hyae^*; Kim ShinYoung; Lee Si Won; Park So Yeon; Han Jung Yeol; Chung Jin Hoon; Kim Moon Young; Yang Jae Hyug; Ryu Hyun Mee

来源：Journal of Assisted Reproduction and Genetics, 2011, 28(1): 85-90.

DOI：10.1007/s10815-010-9485-5

• Androgen receptor
• CAG repeats
• GGC repeats
• c.211G &gt
• A polymorphism
• Preeclampsia

To investigate associations between the androgen receptor (AR) polymorphisms as CAG repeats, GGC repeats and c.211G > A polymorphism and the risk of preeclampsia.
The AR polymorphisms were experienced in 184 preeclamptic patients and 190 normal pregnancies and analyzed by multiple logistic regression.
Women with GGC repeats > 16 were more frequently observed in preeclampsia, compared to those with GGC repeatsa parts per thousand currency sign16 [adjOR (95% CI): 3.64 (1.71-6.23)]. However, no significant differences were observed between the two groups with respect to CAG repeats. The genotypic and allelic frequencies of c.211G > A variant were significantly higher in cases than in controls (P < 0.05 for both). In the combined distribution of these polymorphisms, the highest risk of preeclampsia was found among women with the haplotype as CAG > 20/GA/GGC > 16 [adjOR (95% CI): 4.26 (1.92-12.23)].
Our findings suggest that longer GGC repeats and c.211G > A variant in the AR gene are associated with increased susceptibility to the risk of preeclampsia.

• 出版日期2011-1