Decreased Bc1-6 and increased Blimp-1 in the peritoneal cavity of patients with endometriosis

作者：Yeo S G; Won Y S; Kim Y Il; Lee J W; Choi Y J; Park D C^*

来源：Clinical and Experimental Obstetrics & Gynecology, 2015, 42(2): 156-160.

DOI：10.12891/ceog1818.2015

• Bc1-6
• Blimp-1
• Immunoglobulin
• Endometriosis

Purpose of investigation: The authors investigated the expression patterns of interleulcin (IL)-1 beta and tumor necrosis factor (TNF)-alpha, cytokines associated with peritoneal inflammatory reactions, and of B cell leukemia lymphoma (Bcl)-6 and B lymphocyte inducer of maturation program (Blimp)-1, transcriptional factors associated with inununoglobulin (Ig) production; the concentrations of Igs, and their correlation, in patients with and without endometriosis. Materials and Methods: The authors analyzed the peritoneal fluid of 98 patients, 46 with endometriosis, and 52 with benign tumors. Results: IL-1 beta and TNF-alpha mRNAs and IgG and IgA concentrations were higher in the endometriosis group, but the differences were not statistically significant. However, Bcl-6 mRNA level was significantly lower and Blimp-1 mRNA level was significantly higher in the endometriosis group with significant correlations among transcriptional factors, Igs, and cytoldnes (p < 0.05). Conclusion: Peritoneal immune responses in patients with endometriosis may be due to increased IgG and IgA concentrations, as well as to changes in expression of proinflanunatory cytoldnes and transcriptional factors.

• 出版日期2015