Alveolar gas composition during maximal and interrupted apnoeas in ambient air and pure oxygen

作者：Fagoni Nazzareno^*; Taboni Anna; Vinetti Giovanni; Bottarelli Sara; Moia Christian; Bringard Aurelien; Ferretti Guido

来源：Respiratory Physiology & Neurobiology, 2017, 235: 45-51.

DOI：10.1016/j.resp.2016.10.002

• Interrupted apnoea
• Maximal apnoea
• Oxygen apnoea
• PACO2
• Alveolar gas
• Diaphragmatic contraction

Introduction: We tested the hypothesis that the alveolar gas composition at the transition between the steady phase II (phi 2) and the dynamic phase III (phi 3) of the cardiovascular response to apnoea may lay on the physiological breaking point curve (Lin et al., 1974).
Methods: Twelve elite divers performed maximal and phi 2-interrupted apnoeas, in air and pure oxygen. We recorded beat-by-beat arterial blood pressure and heart rate; we measured alveolar oxygen and carbon dioxide pressures (PAO2 and PACO2, respectively) before and after apnoeas; we calculated the PACO2 difference between the end and the beginning of apnoeas (Delta PACO2).
Results: Cardiovascular responses to apnoea were similar compared to previous studies. PAO2 and PACO2 at the end of phi 2-interrupted apnoeas, corresponded to those reported at the physiological breaking point. For maximal apnoeas, PACO2 was less than reported by Lin et al. (1974). Delta PACO2 was higher in oxygen than in air.
Conclusions: The transition between phi 2 and phi 3 corresponds indeed to the physiological breaking point. We attribute this transition to Delta PACO2, rather than the absolute PACO2 values, both in air and oxygen apnoeas.

• 出版日期2017-1