The Construction of All-Carbon Quaternary Stereocenters by Use of Pd-Catalyzed Asymmetric Allylic Alkylation Reactions in Total Synthesis

作者：Hong Allen Y; Stoltz Brian M^*

来源：European Journal of Organic Chemistry, 2013, 2013(14): 2745-2759.

DOI：10.1002/ejoc.201201761

• Total synthesis
• Asymmetric catalysis
• Natural products
• Palladium
• Allylation
• All-carbon quaternary stereocenters

All-carbon quaternary stereocenters have posed significant challenges in the synthesis of complex natural products. These important structural motifs have inspired the development of broadly applicable palladium-catalyzed asymmetric allylic alkylation reactions of unstabilized non-biased enolates for the synthesis of enantioenriched -quaternary products. This microreview outlines key considerations in the application of palladium-catalyzed asymmetric allylic alkylation reactions and presents recent total syntheses of complex natural products that have employed these powerful transformations for the direct, catalytic, enantioselective construction of all-carbon quaternary stereocenters.

• 出版日期2013-5