Diurnal transcriptome atlas of a primate across major neural and peripheral tissues

作者：Mure, Ludovic S.; Le, Hiep D.; Benegiamo, Giorgia; Chang, Max W.; Rios, Luis; Jillani, Ngalla; Ngotho, Maina; Kariuki, Thomas; Dkhissi-Benyahya, Ouria; Cooper, Howard M.^*; Panda, Satchidananda^*

来源：Science, 2018, 359(6381): 1232-+.

DOI：10.1126/science.aao0318

• CIRCADIAN GENE-EXPRESSION
• LIVER

<jats:title>Daily transcription cycling in the baboon</jats:title>
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Much of our knowledge about the important effects of circadian rhythms in physiology comes from studies of mice, which are nocturnal. Mure
<jats:italic>et al.</jats:italic>
report transcriptional profiles from many tissues and brain regions in baboons over a 24-hour period (see the Perspective by Millius and Ueda). The results emphasize how extensive rhythmic expression is, with more than 80% of protein-coding genes involved. They also highlight unanticipated differences between the mouse and baboon in the cycling of transcripts in various tissues. The findings provide a comprehensive analysis of circadian variation in gene expression for a diurnal animal closely related to humans.
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<jats:italic>Science</jats:italic>
, this issue p.
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; see also p.
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• 出版日期2018-3-16