Anti-TNF alpha therapy and its implication in gynecology and obstetrics

作者：Ducarme G^*; Amate P; Seirafi M; Ceccaldi P F; Bouhnik Y; Luton D

来源：Journal de Gynecologie Obstetrique et Biologie de la Reproduction, 2011, 40(6): 492-497.

DOI：10.1016/j.jgyn.2011.05.009

• Anti-TNF alpha
• Pregnancy
• Immunosuppression
• Infections
• Infertility

Anti-TNF alpha treatments have modified the medical care, the course and the quality of life of the patients with autoimmune rheumatic, cutaneous or bowel inflammatory diseases. On the other hand, these treatments may have potential severe side effects during pregnancy (congenital malformations, fetal infections). Actually, many pregnancies have been reported during anti-TNF alpha exposures, with good maternal and neonatal outcomes. The introduction or the discontinuation of these treatments will always have to be discussed with the specialist of the chronic disease and, ideally, during a preconceptional counselling. In gynecology, anti-TNF alpha drugs may offer a new safe and effective approach to treating patients with recurrent miscarriages or unexplained or failed in vitro fertilization cycles. On the other hand, these treatments significantly increase the risk for serious infections or viral reactivations and may promote gynaecological malignancies. An adapted gynaecological survey is necessary.

• 出版日期2011-10