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摘要
Functionalized and alpha-stabilized derivatives of dialkyl 2{1-[(alkylamino)carbonyl]-2-oxopropyl}-3-(1,1,1-triphenyl-lambda(5)-phosphanylidene)succinate were obtained in excellent yields from the reaction between primary amines, diketene, and dialkyl acetylenedicarboxylate in the presence of triphenylphosphine. Not only the reaction is diastereoselective but also the formed diasteromer has two rotamers that are in equilibrium with each other. (1)H, (13)C, and (31)P NMR showed only one of the two rotamers and thus conversion of Z-isomer into another is negligible at room temperature.
- 出版日期2009-2-2
- 单位浙江大学
