Migration of encephalitogenic CD8 T cells into the central nervous system is dependent on the alpha 4 beta 1-integrin

作者：Martin Blondel Guillaume; Pignolet Beatrice; Tietz Silvia; Yshii Lidia; Gebauer Christina; Perinat Therese; Van Weddingen Isabelle; Blatti Claudia; Engelhardt Britta; Liblau Roland^*

来源：European Journal of Immunology, 2015, 45(12): 3302-3312.

DOI：10.1002/eji.201545632

• alpha 4 beta 1-Integrin
• CD8 T cell
• Junctional adhesion molecule-B
• Migration
• Neuroinflammation

Although CD8 T cells are key players in neuroinflammation, little is known about their trafficking cues into the central nervous system (CNS). We used a murine model of CNS autoimmunity to define the molecules involved in cytotoxic CD8 T-cell migration into the CNS. Using a panel of mAbs, we here show that the alpha 4 beta 1-integrin is essential for CD8 T-cell interaction with CNS endothelium. We also investigated which alpha 4 beta 1-integrin ligands expressed by endothelial cells are implicated. The blockade of VCAM-1 did not protect against autoimmune encephalomyelitis, and only partly decreased the CD8(+) T-cell infiltration into the CNS. In addition, inhibition of junctional adhesion molecule-B expressed by CNS endothelial cells also decreases CD8 T-cell infiltration. CD8 T cells may use additional and possibly unidentified adhesion molecules to gain access to the CNS.

• 出版日期2015-12