A novel strategy for surface modification of superparamagnetic iron oxide nanoparticles for lung cancer imaging

作者：Huang, Gang; Zhang, Chunfu; Li, Shunzi; Khemtong, Chalermchai; Yang, Su-Geun; Tian, Ruhai; Minna, John D.; Brown, Kathlynn C.; Gao, Jinming^*

来源：Journal of Materials Chemistry, 2009, 19(35): 6367-6372.

DOI：10.1039/b902358e

• MAGNETITE NANOPARTICLES
• POLYMERIC MICELLES
• DISSOLUTION
• DELIVERY
• RECEPTOR

Superparamagnetic iron oxide (SPIO) nanoparticles are widely used in magnetic resonance imaging (MRI) as versatile ultra-sensitive nanoprobes for cellular and molecular imaging of cancer. In this study, we report a one-step procedure for the surface functionalization of SPIO nanoparticles with a lung cancer-targeting peptide. The hydrophobic surfactants on the as-synthesized SPIO are displaced by the peptide containing a poly(ethylene glycol)-tethered cysteine residue through ligand exchange. The resulting SPIO particles are biocompatible and demonstrate high T-2 relaxivity. The nanoprobes are specific in targeting alpha(v)beta(6)-expressing lung cancer cells as demonstrated by MR imaging and Prussian blue staining. This facile surface chemistry and the functional design of the proposed SPIO system may provide a powerful nanoplatform for the molecular diagnosis of lung cancer.

• 出版日期2009
• 单位上海交通大学