AMP-activated protein kinase sparks the fire of cardioprotection against myocardial ischemia and cardiac ageing

作者：Gu, Chunhu; Li, Tian; Jiang, Shuai; Yang, Zhi; Lv, Jianjun; Yi, Wei; Yang, Yang^*; Fang, Minfeng^*

来源：Ageing Research Reviews, 2018, 47: 168-175.

DOI：10.1016/j.arr.2018.08.002

• AMP-activated protein kinase
• Myocardial ischemia
• Cardiac ageing
• Glucose metabolism
• Mitochondrial biosynthesis

AMP-activated protein kinase (AMPK) is a pivotal regulator of some endogenous defensive molecules in various pathological processes, particularly myocardial ischemia (MI), a high risk of myocardial infarction. Thereby it is of great significance to explore the inherent mechanism between AMPK and myocardial infarction. In this review, we first introduce the structure and role of AMPK in the heart. Next, we introduce the mechanisms of AMPK in the heart; followed by the energy regulation of AMPK in MI. Lastly, the attention will be expanded to some potential directions and further perspectives. The information compiled here will be helpful for further research and drug design in the future before AMPK might be considered as a therapeutic target of MI.

• 出版日期2018-11
• 单位中国人民解放军空军军医大学; 西北大学; 第四军医大学