A green approach for highly regioselective syntheses of furo[3,2-h]quinolines in aqueous medium

作者：Sarkar Swarbhanu; Pal Rammyani; Chatterjee Nivedita; Dutta Samrat; Naskar Subhendu; Sen Asish Kumar^*

来源：Tetrahedron Letters, 2013, 54(29): 3805-3809.

DOI：10.1016/j.tetlet.2013.05.038

• Furo[3,2-h]quinolines
• Micelle
• Reaction in water
• Cu-free Sonogashira
• 5-exo-Dig cyclization
• One-pot

An environmentally benign, high yielding, and operationally simple protocol has been developed for the regioselective synthesis of furo[3,2-h]quinolines in aqueous micellar medium involving Cu-free domino Sonogashira reaction followed by 5-endo-dig-cyclization of substituted 8-hydroxyquinolines and terminal allcyne by using Pd(C6H5CN)Cl-2 as catalyst and 2-pyridinecarboxaldehyde methylphenyl hydrazone as ligand under aerobic condition.

• 出版日期2013-7-17