An improved methodology for the synthesis of 1 alpha,25-dihydroxy-20-epi-vitamin D-3 (MC 1288) and Gemini analog Ro-438-3582

作者：Santalla Hugo; Martinez Andrea; Garrido Fatima; Gomez Generosa^*; Fall Yagamare^*

来源：Organic Chemistry Frontiers, 2017, 4(10): 1999-2001.

DOI：10.1039/c7qo00381a

Control over the C-20 stereochemistry allows a versatile method to introduce novel side-chains into the vitamin D scaffold. Using our building blocks containing stereodefined stereochemistry at C-20 we demonstrated that we could improve the current synthesis of calcitriol analogs with potentially interesting biological properties.

• 出版日期2017-10-1