A multi-centre randomised controlled trial of Transfusion Indication Threshold Reduction on transfusion rates, morbidity and healthcare resource use following cardiac surgery: Study protocol

作者：Brierley Rachel C M; Pike Katie; Miles Alice; Wordsworth Sarah; Stokes Elizabeth A; Mumford Andrew D; Cohen Alan; Angelini Gianni D; Murphy Gavin J; Rogers Chris A; Reeves Barnaby C^*

来源：Transfusion and Apheresis Science, 2014, 50(3): 451-461.

DOI：10.1016/j.transci.2014.02.020

• Protocol
• Red cell
• Cardiac surgery
• Transfusion
• Restrictive

Thresholds for red blood cell transfusion following cardiac surgery vary by hospital and surgeon. The TITRe2 multi-centre randomised controlled trial aims to randomise 2000 patients from 17 United Kingdom centres, and tests the hypothesis that a restrictive transfusion threshold will reduce postoperative morbidity and health service costs compared to a liberal threshold. Patients consent to take part in the study pre-operatively but are only randomised if their haemoglobin falls below 9 g/dL during their post-operative hospital stay. The primary outcome is a binary composite outcome of any serious infectious or ischaemic event in the first three months after randomisation. Many challenges have been encountered in the set-up and running of the study.

• 出版日期2014-6