Discovery of a novel biomarker in the urine in women with endometriosis

作者：Tokushige Natsuko^*; Markham Robert; Crossett Ben; Ahn Seong B; Nelaturi Vidya L; Khan Alamgir; Fraser Ian S

来源：Fertility and Sterility, 2011, 95(1): 46-49.

DOI：10.1016/j.fertnstert.2010.05.016

• Biomarker
• endometriosis
• urine

Objective: To investigate whether proteins secreted in urine differ between women with and without endometriosis.
Design: Laboratory study using human urine.
Setting: University-based laboratory.
Patient(s): Women with and without endometriosis undergoing laparoscopy, hysteroscopy and curettage.
Intervention(s): Urine collection from women with and without endometriosis.
Main Outcome Measure(s): Proteomic techniques and mass spectrometry to identify proteins secreted in the urine of women with and without endometriosis.
Result(s): On average, 133 proteins were significantly different between women with and without endometriosis. Cytokeratin-19 was highly up-regulated in the urine of women with endometriosis.
Conclusion(s): Cytokeratin-19 may be a valuable urinary biomarker for endometriosis. (Fertil Steril (R) 2011; 95: 46-9.

• 出版日期2011-1