A metabolic aspect of osteoarthritis: lipid as a possible contributor to the pathogenesis of cartilage degradation

作者：Masuko K^*; Murata M; Suematsu N; Okamoto K; Yudoh K; Nakamura H; Kato T

来源：Clinical and Experimental Rheumatology, 2009, 27(2): 347-353.

• Lipid
• chondrocytes
• osteoarthritis
• metabolic disease

Osteoarthritis (OA) is considered to he linked to obesity and body fat mass. Recent investigations, however; are aimed at clarifying the roles of adipose tissue-derived proteins and a wide variety of lipid mediators, including fatty acids, sphingolipids, and eicosanoids, in cartilage degradation in OA, in addition to the effects body weight itself: Here, we review recent progress in studies of OA, focusing on the potential role of lipid mediators in articular cartilage and introducing the concept that "OA is a metabolic disease" in which lipids essentially contribute to the pathophysiology of cartilage degradation.

• 出版日期2009-4
• 单位河北医科大学