New flavonol glycosides and new xanthone from Polygala japonica

作者：Li, T Z; Zhang, W D^*; Yang, G J; Liu, W Y; Liu, R H; Zhang, C; Chen, H S

来源：Journal of Asian Natural Products Research, 2006, 8(5): 401-409.

DOI：10.1080/10286020500172558

• Polygala japonica
• Polygalaceae
• flavonol glycosides
• xanthone
• guazijinxanthone
• polygatin A

Three new flavonol glycosides and a new xanthone were isolated from Polygala japonica HOUTT. with eight known compounds. Their structures were identified as 1,7-dihydroxy-3,4-dimethoxy-xanthone (1), kaempferol-7,4'-dimethyl ether (2), physcion (3), guazijinxanthone (4), rhamnetin (5), polygalin A (6), 3.5.7-trihydroxy-4'-methoxy-flavone-3-O-beta-(D)-galactopyranoside (7), 3,5,3'-trihydoxy-7,4'-dimethoxyflavone-3-O-beta-(D)-galactopyranoside (8), 3,5,3',4'-tetrahydroxy-7-methoxy-flavone-3-O-beta-(D)-galactopyranoside (9), 3,5,3',4'-tetrahydroxy-7-methoxy-flavone-3-O-beta-(D)-glucopyranoside (10), polygalin B (11), polygatin C (12). Among them, compound 4 is a new xanthone, and 6, 11 and 12 are new flavonol glycosides. Compounds 1, 4, 7 and 8 were tested for cytotoxic activity with MITT assays on five human tumor cell lines, K562, A549, PC-3M, HCT-8 and SHG-44. Compound 4 showed cytotoxic activity against all the five cell lines.

• 出版日期2006-8
• 单位中国人民解放军第二军医大学; 上海交通大学