Application of neural networks in structure-activity relationships

作者：Kovesdi I^*; Dominguez Rodriguez MF; Orfi L; Naray Szabo G; Varro A; Papp JG; Matyus P

来源：Medicinal Research Reviews, 1999, 19(3): 249-269.

DOI：10.1002/(SICI)1098-1128(199905)19:3<249::AID-MED4>3.0.CO;2-0

• benzodiazepine receptor
• class I antiarrhythmic agents
• CoMFA
• neural networks
• structure-activity relationships

Methodology and application of artificial neural networks in structure-activity relationships are reviewed focusing on the most frequently used three-layer feedforward back-propagation procedure. Two applications of neural networks are presented and a comparison of the performance with those of CoMFA and a classical QSAR analysis is also discussed.

• 出版日期1999-5