Alternative synthesis of 2-(4-benzoyl-piperazin-1-ylmethyl)-5, 6-dimethoxy-3-methyl-[1,4]benzoquinone

作者:Wang, Jin; Yang, Jian*; Zhou, Rong-Guang; Yang, Bo; Wu, Yuan-Shuang
来源:Journal of Chemical Research, 2011, (7): 431-432.
DOI:10.3184/174751911X13099411630089

摘要

The title compound was prepared by a reaction sequence starting from 2, 3, 4, 5-tetramethoxytoluene via Blanc chloromethylation reaction, oxidation and alkylation. The described method provides a good yield of the heterocyclic-Coenzyme Q analogue and is suitable for the synthesis of other analogues.