A Synthesis of Oseltamivir (Tamiflu) Starting from D-Mannitol

作者:Ko Ji S; Keum Ji E; Ko Soo Y*
来源:Journal of Organic Chemistry, 2010, 75(20): 7006-7009.
DOI:10.1021/jo.101517g

摘要

A sythesis oseltamivir (Tamiflu) was achieved starting from D-mannitol A unique feature of the synthetic route is that an acyelic processor was constructed which was then cyclized in an ultramolecular aldol reaction to form the Tamiflu skeletion Throughout the synthesis well-established. highly efficient reactions were employed, and no protecion/deprotection sequence was needed

  • 出版日期2010-10-15