Discriminative value of platelet size indices for the identification of the mechanism of chemotherapy-induced thrombocytopenia

作者：ten Berg Maarten J; Huisman Albert; van den Bemt Patricia M L A; den Breeijen Hanneke; Egberts Toine C G; van Solinge Wouter W^*

来源：Biomarkers, 2011, 16(1): 51-57.

DOI：10.3109/1354750X.2010.526243

• Biomarker
• mean platelet volume
• platelet distribution width

Context: A biomarker for discriminating mechanisms of chemotherapy-induced thrombocytopenia (CIT) (i.e. increased platelet destruction and decreased platelet production) would be valuable in managing treatment.
Objective: We explored the discriminating value of platelet size indices for this purpose in a population of adult oncology patients.
Materials and methods: Mean platelet volume (MPV) and platelet distribution width (PDW) were compared between patients with (i) thrombocytopenia possibly due to increased platelet destruction; (ii) thrombocytopenia possibly due to decreased platelet destruction; and (iii) no thrombocytopenia.
Results and conclusions: We obtained negative results, suggesting that these indices are not useful for discriminating different CIT mechanisms.

• 出版日期2011-2