Association between cystatin C and the interaction of pulmonary tuberculosis with chronic diseases

作者：Wu, Huan; Xu, Jialing; Wen, Yufeng^*; Dan, Xia; Liu, Mengxue; Ma, Jun; Wu, Zewei; Dong, Hua

来源：Tropical Journal of Pharmaceutical Research, 2017, 16(8): 2007-2012.

DOI：10.4314/tjpr.v16i8.34

• Cystatin C
• Pulmonary tuberculosis
• Chronic diseases
• Inflammation

Purpose: To determine the association between Cystatin C (Cys C) levels and the interaction of pulmonary tuberculosis (PTB) with chronic diseases (CD).
Methods: Participants (n = 356) were selected randomly from The First Affiliated Hospital of Wannan Medical College, China, and divided into 4 groups: normal control group (n = 80), PTB group (n = 98), chronic disease group (n = 146), and PTB combined with chronic disease group (PTB+CD, n = 31). The investigation included information on demographics and analysis of blood samples for Cys C, liver function, renal function, blood glucose and other biochemical indices.
Results: The highest level of Cys C was obtained in PTB+CD group. Before and after adjusting eGFR, there was no association between Cys C and PTB or/and chronic disease. However abnormal levels of Cys C were significantly higher in PTB+CD group after adjusting eGFR (OR = 4.014, p = 0.0125).
Conclusion: Higher levels of Cys C may be associated with chronic diseases co-existing with PTB.

• 出版日期2017-8
• 单位皖南医学院