A facile ZrO2 nanoparticles catalyzed synthesis of 2-amino-5-arylpyrimido[4,5-b]quinolinediones

作者：Mamaghani Manouchehr^*; Moghadam Mona Jamali; Nia Rogheyeh Hossein

来源：Journal of the Iranian Chemical Society, 2017, 14(2): 395-401.

DOI：10.1007/s13738-016-0988-6

• Nanocatalyst
• ZrO2 (NPs)
• Multicomponent
• Pyrimido[4,5-b]quinoline
• 2,6-diaminopyrimidin-4(1H)-one

In this investigation, an efficient and ecofriendly multicomponent reaction is described for the green synthesis of 2-amino-5-arylpyrimido[4,5-b]quinolinedione derivatives using ZrO2 (NPs). In this protocol, the reaction of 2,6-diaminopyrimidin-4(1H)-one, arylaldehyde and 1,3-cyclohexanedione or 5,5-dimethyl-1,3-cyclohexanedione in the presence of ZrO2 (NPs) in ethylene glycol at 120 A degrees C produced the desired products in excellent yields (90-98 %) and short reaction times (8-60 min.). Use of recyclable catalyst, green solvent, easy workup and excellent yields are the notable features of this method.

• 出版日期2017-2