Antimalarial Activity of Ultra-Short Peptides

作者：Perez Picaso Lemuel; Velasco Bejarano Benjamin; Berenice Aguilar Guadarrama A; Argotte Ramos Rocio; Yolanda Rios Maria

来源：Molecules, 2009, 14(12): 5103-5114.

DOI：10.3390/molecules14125103

• tetrapeptides
• antimalarial activity
• Plasmodium berghei
• ultra-short peptides

Ultra-short peptides 1-9 were designed and synthesized with phenylalanine, ornithine and proline amino acid residues and their effect on antimalarial activity was analyzed. On the basis of the IC(50) data for these compounds, the effects of nature, polarity, and amino acid sequence on Plasmodium berghei schizont cultures were analyzed too. Tetrapeptides Phe-Orn-Phe-Orn (4) and Lys-Phe-Phe-Orn (5) showed a very important activity with IC(50) values of 3.31 and 2.57 mu M, respectively. These two tetrapeptides are candidates for subsequent in vivo assays and SARS investigations.

• 出版日期2009-12