Anatomy of corpus callosum in prenatally malnourished rats

作者：Olivares Ricardo^*; Morgan Carlos; Perez Hernan; Hernandez Alejandro; Aboitiz Francisco; Soto Moyano Ruben; Gil Julio; Ortiz Alexis; Flores Osvaldo; Gimeno Miguel; Laborda Jesus

来源：Biological Research, 2012, 45(1): 87-92.

DOI：10.4067/S0716-97602012000100012

• corpus callosum
• prenatal malnutrition
• rat
• splenium

The effect of prenatal malnutrition on the anatomy of the corpus callosum was assessed in adult rats (45-52 days old). In the prenatally malnourished animals we observed a significant reduction of the corpus callosum total area, partial areas, and perimeter, as compared with normal animals. In addition, the splenium of corpus callosum (posterior fifth) showed a significant decrease of fiber diameters in the myelinated fibers without changing density. There was also a significant decrease in diameter and a significant increase in density of unmyelinated fibers. Measurements of perimeter%26apos;s fractal dimensions from sagittal sections of the brain and corpus callosum did not show significant differences between malnourished and control animals. These findings indicate that cortico-cortical connections are vulnerable to the prenatal malnutrition, and suggest this may affect interhemispheric conduction velocity, particular), in visual connections (splenium).

• 出版日期2012