Modular modelling of signalling pathways and their cross-talk

作者：Donaldson Robin; Calder Muffy^*

来源：Theoretical Computer Science, 2012, 456: 30-50.

DOI：10.1016/j.tcs.2012.07.003

• Signalling pathways
• Cross-talk
• Signalling networks
• Modelling
• Biological modules

Signalling pathways are well-known abstractions that explain the mechanisms whereby cells respond to signals. Collections of pathways form networks, and interactions between pathways in a network, known as cross-talk, enables further complex signalling behaviours. While there are several formal modelling approaches for signalling pathways, none make cross-talk explicit; the aim of this paper is to define and categorise cross-talk in a rigorous way. We define a modular approach to pathway and network modelling, based on the module construct in the PRISM modelling language, and a set of generic signalling modules. Five different types of cross-talk are defined according to various biologically meaningful combinations of variable sharing, synchronisation labels and reaction renaming. The approach is illustrated with a case-study analysis of cross-talk between the TGF-beta, WNT and MAPK pathways.

• 出版日期2012-10-19