Antitumour activity of Lycium chinensis polysaccharides in liver cancer rats

作者：Cui, BoKang; Chen, YanFeng; Liu, Su; Wang, Jun; Li, ShuHong; Wang, QiBo; Li, ShengPing; Chen, MinShan; Lin, XiaoJun^*

来源：International Journal of Biological Macromolecules, 2012, 51(3): 314-318.

DOI：10.1016/j.ijbiomac.2012.05.004

• HPLC
• Lycium chinensis polysaccharides
• VEGF
• Cyclin D1
• Chemical analysis

In the present study, polysaccharides were extracted from the Lycium chinensis (LCP). Rats were divided into four groups. Two groups (Groups A) were maintained on the basal diet, whereas the remaining three groups (Groups B, C and D) had free access to the basal diet and were orally fed with LCP at 200 mg/kg b.w. for Group B, 400 mg/kg b.w. for Group C and 600 mg/kg b.w. for Group D, respectively. Following 4 weeks of this dietary regimen, hepatocarcinogenesis was initiated in all animals by a single intraperitoneal DENA (Sigma-Aldrich, St. Louis, MO, USA) injection at a dose of 200 mg/kg body weight (mixed with peanut oil). Results still showed that L. chinensis polysaccharides (LCP) increased spleen, thymus indexs, antioxidant enzymes activities and decreased oxidative injury. In addition, LCP still significantly affect VEGF and Cyclin D1 proteins expression in liver cancer rats. It can be concluded that LCP exhibited remarkable protective effects against diethylnitrosamine (DEN)-induced oxidative hepatic injury in liver cancer rats.

• 出版日期2012-10
• 单位中山大学; 广东省药品检验所（广东省药品质量研究所、广东省口岸药品检验所）