New click-chemistry methods for 1,2,3-triazoles synthesis: recent advances and applications

作者：Totobenazara Jane^*; Burke Anthony J

来源：Tetrahedron Letters, 2015, 56(22): 2853-2859.

DOI：10.1016/j.tetlet.2015.03.136

• 1,2,3-Triazoles
• Click-chemistry
• Metal-free cycloaddition
• Regioselectivity
• Amide isosters

1,2,3-Triazoles find applications in several major technological areas, and especially in drug discovery. The click-chemistry approaches based on Huisgen's cycloaddition reaction are particularly attractive and have received enormous attention over the last decade and a half, due to their utility in preparing compounds with diverse applications, from drugs to linkers for bioconjugation.

• 出版日期2015-5-27