A preliminary association study between brain-derived neurotrophic factor (BDNF) haplotype and late-onset depression in mainland Chinese

作者：You, Jiayong; Yuan, Yonggui^*; Zhang, Zhijun; Zhang, Xiangrong; Li, Hailin; Qian, Yun

来源：Journal of Affective Disorders, 2010, 120(1-3): 165-169.

DOI：10.1016/j.jad.2009.04.032

• Late-onset depression (LOD)
• Brain-derived neurotrophic factor (BDNF)
• Allele
• Genotype
• Haplotype

Objective: The present Study aimed to assess the association of genotypes and haplotypes in brain-derived neurotrophic factor (BDNF) polymorphisms with late-onset depression (LOD) in a Chinese Han population. @@@ Method: 144 subjects with LOD and 110 control Subjects were recruited for the study, assessed using the Hamilton Rating Scale for Depression, and genotyped for 712G/A, 270C/T, 196A/G and 11757G/C variants by polymerase chain reaction. @@@ Results: No differences were found in the frequencies of the alleles and genotypes of tested BDNF gene between LOD patients and normal group. Interestingly, the distributions of 712G-270T, 196A-11757G, 196G-11757C, 712G-196A-11757G, 712G-196G-11757C, 270C-196A-11757G, 270C-196G-11757C, 712G-270C-196A-11757G, 712G-270C-196G-11757C haplotypes were significantly higher in LOD compared to healthy controls (all P<0.05). @@@ Conclusion: The results tentatively suggest that BDNF haplotypes might be the susceptibility for LOD.

• 出版日期2010-1
• 单位南京医科大学; 东南大学