Neurotrophin delivery using nanotechnology

作者：Angelova Angelina^*; Angelov Borislav; Drechsler Markus; Lesieur Sylviane

来源：Drug Discovery Today, 2013, 18(23-24): 1263-1271.

DOI：10.1016/j.drudis.2013.07.010

Deficits or overexpression of neurotrophins cause neurodegenerative diseases and psychiatric disorders. These proteins are required for the maintenance of the function, plasticity and survival of neurons in the central (CNS) and peripheral nervous systems. Significant efforts have been devoted to developing therapeutic delivery systems that enable control of neurotrophin dosage in the brain. Here, we suggest that nanopaiticulate carriers favoring targeted delivery in specific brain areas and minimizing biodistribution to the systemic circulation should be developed toward clinical benefits of neuroregeneration. We also provide examples of improved targeted neurotrophin delivery to localized areas in the CNS.

• 出版日期2013-12