Processed Panax ginseng, Sun Ginseng Increases Type I Collagen by Regulating MMP-1 and TIMP-1 Expression in Human Dermal Fibroblasts

作者：Song Kyu Choon; Chang Tong Shin; Lee Hyejin; Kim Jinhee; Park Jeong Hill; Hwang Gwi Seo^*

来源：Journal of Ginseng Research, 2012, 36(1): 61-67.

DOI：10.5142/jgr.2012.36.1.61

• Panax ginseng
• Sun ginseng (SE)
• Type I collagen
• Matrix metalloproteinase-1
• Human skin fibroblasts

In the present study, effects of sun ginseng (SG) on the collagen synthesis and the proliferation of dermal fibroblast were investigated. Collagen synthesis was measured by assaying procollagen type I C-peptide production. In addition, the level of matrix metalloproteinase (MMP)-1 was assessed by western blot analysis. SG suppressed the MMP-1 protein level in a dose-dependent manner. In contrast, SG dose-dependently increased tissue inhibitors of MMP (TIMP)-1 production in fibroblasts. SG increased type I collagen production directly and/or indirectly by reducing MMP-1 and stimulating TIMP-1 production in human dermal fibroblasts. SG dose-dependently induced fibroblast proliferation and this, in turn, can trigger more collagen production. These results suggest that SG may be a potential pharmacological agent with anti-aging properties in cultured human skin fibroblast.

• 出版日期2012-1