Antifungal activity of thymol against clinical isolates of fluconazole-sensitive and -resistant Candida albicans

作者：Guo Na; Liu Jingbo; Wu Xiuping; Bi Xingming; Meng Rizeng; Wang Xuelin; Xiang Hua; Deng Xuming^*; Yu Lu

来源：Journal of Medical Microbiology, 2009, 58(8): 1074-1079.

DOI：10.1099/jmm.0.008052-0

Thymol (THY) was found to have in vitro antifungal activity against 24 fluconazole (FLC)-resistant and 12 FLC-susceptible clinical isolates of Candida albicans, standard strain ATCC 10231 and one experimentally induced FLC-resistant C. albicans S-1. In addition, synergism was observed for clinical isolates of C. albicans with combinations of THY-FLC and THY-amphotericin B (AMB) evaluated by the chequerboard microdilution method. The interaction intensity was determined by spectrophotometry for the chequerboard assay, and the nature of the interactions was assessed using two non-parametric approaches [fractional inhibitory concentration index (FICI) and Delta E models]. The interaction between THY-FLC or THY-AMB in FLC-resistant and -susceptible strains of C. albicans showed a high percentage of synergism by the FICI method and the Delta E method. The Delta E model gave results consistent with FICI, and no antagonistic action was observed in the strains tested.

• 出版日期2009-8
• 单位吉林大学