科研之友
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摘要
The detailed monitoring of a foal's critical neonatal period from the passive, intrauterine stage to the active and living equine neonate stage requires specific procedures. The period of cardio-respiratory and metabolic adaptation during transition from the passive intrauterine to the active extrauterine stage is very critical for the equine neonate. The aim of the study was to continuously determine the acid-base-status within the first 96 hours of a foal's life. Forty-one foals were provided by a German warmblood breeding farm. All foals were developed via naturalis after an unproblematic gestation (334 +/- 10 d). Thirt-seven foals were mature and eutroph, 4 foals were hypotroph. The foals were closely monitored for any kind of abnormality in development (Apgar Score and the Giessen prophylaxis score system 1 and 2). Eleven blood samples were taken of each foal within the first 96 hours post natum (p. n.). The pH value, partial pressure of carbon dioxide and current base excess were measured stall side with a battery-operated blood gas analyzer (AVL, Opti 1). The foals were devided into two groups, vital foals (n = 30) and foals with mild impairment of vital functions within the first 24-48 hours of life. The pH- and ABE-value of all foals increased within the first 60 minutes (p = 0,01). Then the pH-values decreased temporarily (24. h p. n.; p = 0,01), followed by another increase. At the some time, ABE decreased after the 2. hour (p = 0,05-0,01), until they increased again after 24 h p. n. The curves of pH- and ABE-values progressed differently in the first 96-hour-period, so that the population could be divided into four subgroups. Only in 22% of the foals the pH increased steadily. The majority of newborn foals (78 %) showed a distinct depression in pH development at different times post natum, the current base excess demonstrated a constant parallelism to the pH value, including the period of stagnation. This study showed that within a small equine population, underlying the same management and feeding conditions, the majority of equine neonates will show a decrease in their acid-base status at different times. These changes in acid-base status correlated with abnormal clinical findings in 11 foals. The results of this study emphasize the importance of close monitoring of newborn foals during the first 4 days of life, as they are at risk of being compromised during respiratory and metabolic adaptation.
- 出版日期2011-6
