Adult T-cell leukemia-lymphoma associated with follicular mucinosis

作者：Wada Tamae; Yoshinaga Eiji; Oiso Naoki; Kawara Shigeru; Kawada Akira^*; Kozuka Takehito

来源：Journal of Dermatology, 2009, 36(12): 638-642.

DOI：10.1111/j.1346-8138.2009.00722.x

• adult T-cell leukemia-lymphoma
• epidermotropism
• follicular mucinosis
• folliculotropism

Follicular mucinosis (alopecia mucinosa) is often associated with malignancies including mycosis fungoides and Sezary syndrome, but not adult T-cell leukemia-lymphoma (ATLL). We report a 49-year-old male patient who had pruritic follicular papules and erythemas clinically, and follicular and perifollicular infiltrates and follicular mucin deposition histopathologically. The patient showed 11% of flower-shaped atypical lymphocytes in blood examination and positive human T-cell leukemia virus type 1 antibody in serology, consistent with the chronic type of ATLL. This case seems to be a very rare association of follicular mucinosis and chronic ATLL, suggesting that malignant T cells may have a feature of folliculotropism as well as epidermotropism.

• 出版日期2009-12