Direct Synthesis of Diastereomerically Pure Glycosyl Sulfonium Salts

作者：Mydock Laurel K; Kamat Medha N; Demchenko Alexei V^*

来源：Organic Letters, 2011, 13(11): 2928-2931.

DOI：10.1021/ol2009818

It is reported that stable glycosyl sulfonium salts can be generated via direct anomeric S-methylation of ethylthioglycosides. Mechanistically, this pathway represents the first step in the activation of thioglycosides for glycosidation; however, it can further allow for the synthesis and isolation of quasi-stable sulfonium ions, representing a new approach for studying these key intermediates.

• 出版日期2011-6-3