Assessment of endothelial and renal dysfunction in patients after renal transplantation

作者：Wang, Zhe; Wang, Wei; Jiang, Yihang; Zhang, Min; Yin, Hang^*

来源：International Journal of Clinical and Experimental Medicine, 2018, 11(3): 2566-2571.

• Endothelial dysfunction
• reactive hyperemia index
• kidney transplantation
• renal fibrosis
• renal function

Objective: Renal failure and cardiovascular events are the most severe complications of renal transplantation, and significantly affect long term survival. A common cause of renal failure is renal fibrosis in which endothelial dysfunction plays an important role. Endothelial dysfunction as an independent factor is directly involved in renal interstitial fibrosis. Thus, the assessment of endothelial dysfunction is very important after renal transplantation. Methods: 79 consecutive patients receiving renal transplantation were recruited from the Urology Clinic between July 2014 and July 2015. RHI was employed to assess endothelial function, blood creatinine, and glomerular filtration rate (eGFR). Mean arterial pressure (MAP) was detected on recruitment and at 12 and 24 months after recruitment. Results: RHI has close relationships with creatinine and eGFR (R = -0.881 and 0.942, respectively; P = 0.0001). RHI is also related to the time after renal transplantation (R = -0.438, P = 0.01). Multivariate linear model analysis shows MAP and eGFR are predictors of RHI after renal transplantation. At 24 months, RHI (1.58 +/- 0.29) was significantly lower than on recruitment (1.68 +/- 0.31) (P = 0.04). The blood creatinine in patients with endothelial dysfunction was significantly higher than in those with normal endothelial 126.3 +/- 45.3 vs 98.4 +/- 44.1, P<0.05). The eGFR in patients with endothelial dysfunction was markedly lower than in those with normal endothelial 59.3 +/- 15.2 vs 70.1 +/- 16.4, P < 0.05). The kidney function remained unchanged in patients with normal endothelial function. Conclusion: At 6 months after renal transplantation, endothelial dysfunction deteriorates over time and has a close relationship with renal dysfunction.

• 出版日期2018
• 单位首都医科大学