Anti-SOX1 antibodies in patients with paraneoplastic and non-paraneoplastic neuropathy

作者：Tschernatsch M^*; Singh P; Gross O; Gerriets T; Kneifel N; Probst C; Malas S; Kaps M; Blaes F

来源：Journal of Neuroimmunology, 2010, 226(1-2): 177-180.

DOI：10.1016/j.jneuroim.2010.07.005

• Paraneoplastic neurological syndromes
• Anti-glial nuclear antibody
• Small cell lung cancer
• Peripheral neuropathy
• SOX1

Anti-SOX1 antibodies have been described to be positive in patients with paraneoplastic Lambert-Eaton myasthenic syndrome and, in a lower amount, in patients with anti-Hu positive paraneoplastic neurological syndromes, and with SCLC alone, respectively. We found 5/32 patients with paraneoplastic neuropathy and, surprisingly, 4/22 patients with neuropathy of unknown origin positive for anti-SOX1 antibodies, whereas no patient with inflammatory neuropathy and no healthy controls showed any reactivity (p=0.007). All patients with neuropathy of unknown origin where followed up for four years without diagnosis of a tumour so far. Anti-SOX1 antibodies are associated with paraneoplastic neuropathies and may define another group of non-paraneoplastic, immune-mediated neuropathies.

• 出版日期2010-9-14