A reciprocal relationship exists between non-steroidal anti-inflammatory drug-activated gene-1 (NAG-1) and cyclooxygenase-2

作者：Iguchi Genzo; Chrysovergis Kali; Lee Seong Ho; Baek Seung Joon; Langenbach Robert; Eling Thomas E^*

来源：Cancer Letters, 2009, 282(2): 152-158.

DOI：10.1016/j.canlet.2009.03.006

• GDF-15
• NAG-1
• COX-2
• Colorectal cancer

Non-steroidal anti-inflammatory drug (NSAID)-activated gene-1 (NAG-1) and COX-2 are involved in cellular processes such as inflammation, apoptosis, and tumorigenesis. To address the relationship between COX-2 and NAG-1 expression, we investigated the expression of NAG-1 and COX-2 in normal and tumor tissue from human patients, Apc(Min/ ) mice, and COX-2(-/-) mice. While COX-2 expression is highly induced in tumor tissue, NAG-1 expression is reduced. Furthermore, PGE2 reduces NAGA while celebrex induces NAGA expression. The results suggest that a possible inverse relationship exists between the expression of NAGA and COX-2 in tumor formation of colon tissue. Published by Elsevier Ltd.

• 出版日期2009-9-18