A Meta-analysis of the Therapeutic Effects of Amitriptyline for Treating Irritable Bowel Syndrome

作者：Chao, Guan-qun; Zhang, Shuo^*

来源：Internal Medicine, 2013, 52(4): 419-424.

DOI：10.2169/internalmedicine.52.9147

• irritable bowel syndrome
• amitriptyline
• meta-analysis

Objective We aimed to evaluate the efficacy of amitriptyline as a therapeutic option for irritable bowel syndrome (IBS) through a meta-analysis of randomized controlled trials. @@@ Methods For the years from 1966 until May 2012, PubMed, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials were searched for double-blind, placebo-controlled trials investigating the efficacy of amitriptyline in the management of IBS. @@@ Results Four randomized, placebo-controlled clinical trials met our criteria and were included in the meta-analysis. The pooled relative risk for clinical improvement with amitriptyline therapy was 4.18 (95% CI: 2.00 to 8.77, p=0.0001). @@@ Conclusion It was thus concluded that amitriptyline exhibits a clinically and statistically significant control of IBS symptoms.

• 出版日期2013
• 单位浙江大学; 浙江中医药大学