A convenient method for the synthesis and resolution of Troger base

作者:Satishkumar Sakilam; Periasamy Mariappan*
来源:Tetrahedron: Asymmetry , 2006, 17(7): 1116-1119.
DOI:10.1016/j.tetasy.2006.04.002

摘要

Racemic Troger base 1 can be readily obtained by the condensation of 4-toluidine and paraformaldehyde in the presence of Lewis acids and easily resolved via the preparation of diastereomeric aggregates using chiral dibenzoyl-L-tartaric acid 2.

  • 出版日期2006-4-3