Diffusion Tensor Imaging Reveals White Matter Changes Associated With Cognitive Status in Patients With Parkinson's Disease

作者：Deng, Bingmei; Zhang, Yuhu; Wang, Lijuan^*; Peng, Kairun; Han, Lixin; Nie, Kun; Yang, Hongjun; Zhang, Li; Wang, Jun

来源：American Journal of Alzheimer's Disease and Other Dementias, 2013, 28(2): 154-164.

DOI：10.1177/1533317512470207

• Parkinson's disease
• cognitive impairment
• white matter
• diffusion tensor imaging
• fractional anisotropy

Objective: Cognitive deficit and white matter alteration relationships in Parkinson's disease (PD) were investigated. Methods: Comparison of 64 patients with PD (M: F, 34: 30; 64.4 +/- 10.4 years) classified as cognitively normal (PD-CogNL, n = 24), mild cognitive impairment (PD-MCI, n = 30), and dementia (PD-D, n = 10) with 21 healthy participants (M: F, 10: 11; 60.1 +/- 13.6 years) was conducted using white matter fractional anisotropy (FA), region-of-interest analysis, and diffusion tensor imaging. Results: The PD-D and PD-MCI exhibited higher Unified Parkinson's Disease Rating Scale motor scores (P < .001; P < .01) and Hoehn-Yahr stages (P < .001; P < .05) and FA reductions in left frontal/right temporal white matter and bilateral anterior cingulated bundles. Largest FA reductions occurred in PD-D left anterior cingulated bundle and corpus callosum splenium. Disease durations of PD-D 6.8 +/- 6.86, PD-MCI 5.1 +/- 2.9, and PD-CogNL 4.7 +/- 3.4 years, suggesting progressive deterioration. Conclusions: Cerebral white matter deterioration may underlie progressive cognitive impairment in PD.

• 出版日期2013-3
• 单位广东省人民医院; 南方医科大学