Direct asymmetric hydrogenation of α-keto acids by using the highly efficient chiral spiro iridium catalysts

作者：Yan, Pu-Cha; Xie, Jian-Hua; Zhang, Xiang-Dong; Chen, Kang; Li, Yuan-Qiang; Zhou, Qi-Lin; Che, Da-Qing^*

来源：Chemical communications, 2014, 50(100): 15987-15990.

DOI：10.1039/c4cc07643e

• INTRAMOLECULAR CANNIZZARO REACTION
• RECOMBINANT ESCHERICHIA-COLI
• HYDROXY CARBOXYLIC-ACIDS
• FRIEDEL-CRAFTS REACTION
• ENANTIOSELECTIVE HYDROGENATION
• METHYL (R)-O-CHLOROMANDELATE
• SELECTIVE REDUCTIONS
• DIPHOSPHINE LIGANDS
• BETA-KETO
• KETOESTERS

A new efficient and highly enantioselective direct asymmetric hydrogenation of alpha-keto acids employing the Ir/SpiroPAP catalyst under mild reaction conditions has been developed. This method might be feasible for the preparation of a series of chiral alpha-hydroxy acids on a large scale.

• 出版日期2014
• 单位南开大学