New options in the treatment of acute heart failure

作者：Link A^*; Boehm M

来源：Internist, 2014, 55(6): 655-662.

DOI：10.1007/s00108-013-3426-1

• Diuretics
• Inotropic agents, positive cardiac
• Vasodilator agents
• Vasopressin V2 receptor antagonist
• Serelaxin protein, human

Acute heart failure is defined as the acute onset of symptoms due to hear failure necessitating emergency therapy. The in-hospital mortality rate ranges up to 10 % and in cardiogenic shock is 50-70 %. In acute heart failure, rapid diagnosis and causal therapy are necessary to avoid cardiogenic shock. In cases of acute coronary syndromes, primary percutaneous intervention should be performed immediately. Medical and apparative treatment strategies focus on decreasing pulmonary congestion, afterload, and neurohormonal activation in order to improve hemodynamics and reduce symptoms of dyspnea. In contrast to chronic heart failure, no medical therapy has been able to reduce mortality rates in acute heart failure. However, new medical therapies should at least improve clinical symptoms of congestion and favorably reduce cardiovascular events, re-hospitalization, and mortality rates.

• 出版日期2014-6